The selection gradient points to migration of the mutated form of SLC24A5 Out-of-India. The mutation is 100% selective in Europe (along with Lactase persistence). Invariably, 100% selection in any area means that the mutation arose in the opposite where the heterozygotes predominate. There are a number of papers making ridiculous and stretched arguments against the evidence of the selection gradient.
The mutation probably arose in association with leprosy in the Indus Valley.
The mutation probably arose in association with leprosy in the Indus Valley.